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American Society of Microbiology ABMM Sample Questions:
1. A public health investigation is underway following several cases of encephalitis in a specific geographic region during the summer months. Mosquitoes are abundant in the area. Serological testing of patient CSF samples reveals IgM antibodies against a flavivirus. The MOST likely causative agent is:
A) Eastern equine encephalitis virus
B) Jamestown Canyon virus
C) Rabies virus
D) West Nile virus
2. A research team is investigating the development of a novel vaccine against influenza virus. They are focusing on conserved epitopes within the hemagglutinin (HA) and neuraminidase (NA) proteins to elicit broadly neutralizing antibodies. Which of the following approaches is MOST likely to achieve this goal?
A) Designing a subunit vaccine that presents highly variable regions of HA and NA.
B) Administering high doses of inactivated influenza vaccine annually.
C) Utilizing a recombinant viral vector to deliver conserved epitopes of HA and NA.
D) Developing a live-attenuated influenza vaccine containing multiple serotypes.
3. A sputum sample from a patient with suspected pulmonary tuberculosis is submitted for AFB smear and culture. The smear is reported as positive for acid-fast bacilli (4+). Which method is considered the gold standard for confirming the identification of Mycobacterium tuberculosis complex from culture?
A) Nucleic acid amplification test (NAAT) targeting specific MTC sequences
B) HPLC analysis of mycolic acids
C) Niacin accumulation test
D) Growth rate and colony morphology on Löwenstein-Jensen media
4. A patient with a history of travel to a rural area develops a febrile illness with jaundice and dark urine.
Peripheral blood smear reveals intraerythrocytic parasites with a characteristic Maltese cross morphology.
The MOST likely causative agent is:
A) Plasmodium vivax
B) Trypanosoma brucei
C) Babesia microti
D) Plasmodium falciparum
5. A clinical microbiology laboratory is performing quality control on Gram stain reagents. A control slide containing Escherichia coli and Staphylococcus aureus shows both organisms staining purple after the complete staining procedure. The MOST likely cause of this error is:
A) Insufficient washing after crystal violet.
B) Insufficient application of crystal violet.
C) Over-decolorization with alcohol-acetone.
D) Omission of the iodine mordant.
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: C | Question # 3 Answer: A | Question # 4 Answer: C | Question # 5 Answer: D |
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